20 Oct Australia and New Zealand are among the safest countries in the world to have IVF

IVF success rates have improved significantly over the last 10 years, a new report by UNSW medical researchers has shown.

The live birth rate per initiated IVF cycle in women using their own eggs has increased by 18% overall, with even steeper improvements in older age groups.

“For example, in women aged 35-39, the live birth rate per cycle started has increased from 19% to 23%, representing a 20% relative increase in success rates,” says Professor Georgina Chambers, the lead author of UNSW’s report.

“And in those aged 40-44, the live birth rate has increased to 10%, representing a 27% increase in success rates over the last 10 years.”

In 2019 – the most recent year for which data are available – there were 16,310 babies born through IVF treatment performed in Australia and New Zealand. There were 88,929 initiated IVF cycles in 2019, a 6.2% increase on 2018 in Australia.

Not all cycles reach embryo transfer, but of those that do, we also see significant improvements.

The overall live birth rate per embryo transfer has increased from 22% in 2010 to 28% in 2019. It was higher in younger women – the live birth rate per embryo transfer was 35.1% for fresh cycles and 34.1% for thaw cycles in women aged between 30 and 34 years, whereas in women older than 44 years, the live birth rate per embryo transfer was 1.7% for fresh cycles and 9.2% for thaw cycles.

Dr Petra Wale, a senior embryologist and Vice President of the Fertility Society of Australia and New Zealand says “The improved success rates are due to many factors, including advancements in laboratory techniques and improvements in the overall management of couples experiencing infertility, such as lifestyle interventions, improved diagnostic capabilities, and in some cases surgery prior to IVF.

“Every aspect of an IVF cycle – from ovarian stimulation protocols, the culture media that embryos are grown in, to the selection of the best embryo at optimal stage of development– have seen incremental improvements over the last decade.”

Frozen cycles are more successful than fresh, with twins and triplets rates down

The biggest improvements happened in live birth rates in frozen embryo transfers vs. fresh transfers.

“Doing this allows us to transfer the embryo into the womb when the body is more receptive, and the evolution of rapid freezing techniques – called vitrification – allows us to cryopreserve embryos more effectively than older freezing methods,” Prof. Rombauts says.

The multiple birth rate in Australia and New Zealand – the proportion of twins and triplets born through IVF – has decreased from 7.9% in 2010 to 2.9% in 2019. This improvement has been driven by the increased proportion of IVF cycles where only a single embryo is transferred, up from 70% in 2010 to 92% in 2019.

“This continuing trend in the very low multiple birth rate is quite extraordinary, and we are really proud that Australia and New Zealand are among the safest countries in the world to have IVF,” says Prof. Rombauts.

Information:

UNSWm has developed the YourIVFSuccess website which includes a Patient Estimator that allows patients to estimate their chances of successfully having a baby using IVF based on their individual characteristics. It also includes a searchable database of the success rates for all accredited IVF clinics in Australia.  

Key stats from the 2019 ANZARD report

• There were 88,929 assisted reproductive technology (ART) treatment cycles reported from Australian and New Zealand clinics in 2019 (81,049 and 7880 respectively) representing increases of 6.2% in Australia and 2.0% in New Zealand from 2018.
• Of the 88,929 initiated ART cycles, there we 16,310 live births.
• Women used their own eggs in nearly 95% of cycles in 2019; 57.9% were fresh cycles and 36.7% were thaw cycles.
• The live birth rate per initiated cycle was 16.5% for autologous fresh (excluding freeze-all) cycles and 28.9% for autologous frozen/thaw cycles.
• Single embryo transfer rates have increased from 85.7% of embryo transfer procedures in 2015 to 91.9% in 2019.
• The multiple birth rate has decreased from 4.4% in 2015 to 2.9% in 2019.
• Data was submitted by all Australian and New Zealand IVF clinics, and presents information about IVF cycles undertaken in 2019 and the resulting babies born in 2019 and 2020.

The ANZARD report Assisted Reproductive Technology in Australia and New Zealand 2019 (ANZARD) report is funded by the Fertility Society of Australia and New Zealand (FSANZ) and contains data from all 95 IVF clinics operating in the two countries.